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Building Bridges from Genomes to Phenomes: A 2020 SICB Symposium

The members of the AG2P RCN are leading a new Symposium for the January 2020 Annual Meeting of the Society for Integrative and Comparative Biology (SICB).  This society-wide Symposium is entitled: “Building Bridges from Genomes to Phenomes: Molecules, Methods and Models”.   At its core, the 2020 symposium- with associated complementary oral and poster paper sessions, lunch planning session and policy workshop- will delve into recent progress linking phenotype plasticity to changes at the level of the genome, epigenome, proteome, and metabolome, while exploring the boundaries between variation and speciation. Presentations, discussions and syntheses will focus on new approaches, models and methodological challenges in melding different types of datasets (genomic, transcriptomic, epigenetic, proteomic, metabolomic) to address questions about linkages between the genome and phenome in non-model organisms. Invited Speakers, their research topics and additional information on the Symposium can be found above on the Speaker information page. We seek input from the larger community regarding what they see as important topics to be covered in the workshops and its final policy paper.  Feedback will be used to begin compiling a list of promising questions, research directions, major hurdles and vision statements from a wide community of investigators.

Welcome to the Animal Genome to Phenome Research Coordination Network Website

Welcome to the Animal Genome to Phenome Research Co-ordination Network Website

Understanding the relationship between an organism’s DNA (the genome) and the set of phenotypic characteristics that result from genomic expression (the phenome) is a central challenge in biology. High throughput sequencing and phenotypic data from multiple species provides an opportunity for comparative analysis of genome to phenome data. The objective of the Animal Genome to Phenome Network (AG2PN) Research Collaboration Network (RCN) is to promote comparative analysis of vertebrate and invertebrate animals to enrich our understanding of the relationship between genomes and phenomes. The AG2PN will bring together groups using diverse experimental approaches to understand how the genome ultimately manifests the phenome. The AG2PN will provide tools necessary for scientists to exploit comparative genomics approaches to understand genome to phenome relationships. In addition, the activities of the AG2PN will provide training for undergraduates, graduate students and post-doctoral fellows in the science of comparative biology and genome to phenome relationships. Participation of researchers from universities and colleges serving historically underrepresented groups will be particularly encouraged. The AG2PN will also generate educational modules to further enhance student training in G2P concepts. All of the resources developed by the AG2PN will be freely available to the scientific community, communicated at scientific meetings, and published in peer-reviewed journals.
A major objective of the AG2PN will be to encourage researchers to leave their silos and develop collaborative teams that will exploit comparative approaches to enhance our understanding of genome to phenome relationships. The AG2P RCN goals include: Establishing an international AG2PN with scientists studying a diverse range of animals; AG2PN activities that will directly foster the development of comparative studies by promoting standardization of experimental approaches, data and metadata collection and bioinformatic analyses; promoting new collaborations and proposals among scientists from different specialties through international meetings, web sites, publications and social media; and promoting understanding of comparative genomic studies through the development of training modules using diverse educational modalities. Ultimately, this RCN will improve our understanding of the relationships between selective pressures, genomic changes and phenotypic outcomes. The standards developed by this RCN will find applicability far beyond the science directly affected by the AG2P network. These standards will facilitate laboratory work and data comparability across a broad range of species and studies.